POLONEZ BIS

PROJECT TITLE: „Enzyme Responsive Nanoscale Supramolecular Capsules with Application in Anticancer Drug Delivery”
PROJECT ACRONYM: ERNS Cap
PROJECT ID: 2022/45/P/ST4/00989
PROJECT IMPLEMENTATION TIME: 01.10.2023-30.09.2025

ABOUT PROJECT:
Cancer remains one of the leading causes of death worldwide, yet despite significant research investment a conventional chemotherapeutic has yet to be reported that does not suffer from side effects attributed to the non-selective delivery of the anticancer agent to both healthy and cancerous cells. We aim to develop molecular containers capable of encapsulating commonly prescribed chemotherapeutics. In their encapsulated form the anticancer agents would been unable to interact with key biological agents and thus would not be expected to display toxicity or anticancer activity. Rapid degradation of the capsule in response to elevated levels of enzymes and biomolecules that have been identified as cancer markers would result in the release of the anticancer agent and provide an unexplored methodology for the selective release of active anticancer drugs in cancer cells. The development of a selective method for the delivery of anticancer agents to tumor cells would result in a significant increase in the quality of life for patients receiving anticancer drugs.

RESARCH GROUP INFORMATION:

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